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Intracellular and extracellular TGF-β signaling in cancer: some recent topics
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 387-411 doi: 10.1007/s11684-018-0646-8
Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. Although tumor-suppressive roles of TGF-β have been extensively studied and well-characterized in many cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancer. This review will focus on recent findings regarding epithelial-mesenchymal transition (EMT) induced by TGF-β, in relation to crosstalk with some other signaling pathways, and the roles of TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer progression. Recent findings also strongly suggested that targeting TGF-β signaling using specific inhibitors may be useful for the treatment of some cancers. TGF-β plays a pivotal role in the differentiation and function of regulatory T cells (Tregs). TGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressed on the surface of Tregs contains glycoprotein A repetitions predominant (GARP, also known as leucine-rich repeat containing 32 or LRRC32). Inhibition of the TGF-β activities through regulation of the latent TGF-β complex activation will be discussed.
关键词: TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 1038-1050 doi: 10.1007/s11705-022-2279-3
关键词: cellulose polyelectrolytes phase change materials thermal energy storage light-to-thermal conversion
Beyond bag of latent topics: spatial pyramid matching for scene category recognition
Fu-xiang LU,Jun HUANG
《信息与电子工程前沿(英文)》 2015年 第16卷 第10期 页码 817-828 doi: 10.1631/FITEE.1500070
关键词: Scene category recognition Probabilistic latent semantic analysis Bag-of-words Adaptive boosting
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 390-395 doi: 10.1007/s11684-009-0087-5
关键词: Epstein-Barr virus latent membrane protein 2 nasopharyngeal carcinoma humoral immunity
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
《医学前沿(英文)》 2012年 第6卷 第3期 页码 243-247 doi: 10.1007/s11684-012-0201-y
关键词: LADA diagnostic criteria autoantibodies insulin independence age of diagnosis
Combination form analysis and experimental study of mechanical properties on steel sheet glass fiber
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 834-850 doi: 10.1007/s11709-021-0743-7
关键词: steel sheet GFRP composite bar combination form numerical modeling mechanical properties test strength
General closed-form inverse kinematics for arbitrary three-joint subproblems based on the product of
《机械工程前沿(英文)》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0681-7
关键词: inverse kinematics Paden–Kahan subproblems three-joint subproblems product of exponential closed-form solution
堆积床相变储热系统中径向孔隙率振荡分布对热性能的影响 Article
刘红兵, 赵长颖
《工程(英文)》 2021年 第7卷 第4期 页码 515-525 doi: 10.1016/j.eng.2020.05.020
由于具有较高的储热能力和传热速率,堆积床相变储热被认为是一种很有潜力的储热方法。在堆积床中,壁面效应会影响相变胶囊的填充结构,从而引起径向孔隙率的振荡。本研究建立了一个基于球体实际堆积过程的三维堆积床相变储热模型,以描述径向孔隙率的振荡分布,并分析了其内部的流动和传热情况。通过在堆积床中沿径向不同位置截取圆柱面,揭示了相变胶囊的排列与径向孔隙率之间的对应关系。径向孔隙率的振荡分布导致换热流体速度呈不均匀分布,因此相变材料的径向温度分布和液相分数分布进一步受到影响。此外,本文讨论了不同的无量纲参数(如管与胶囊的直径比、雷诺数和史蒂芬数)对换热流体和相变材料径向特性的影响。结果表明,不同的直径比对应于不同的径向孔隙率分布。此外,随着直径比的增加,在壁面附近区域换热流体速度显著变化,而中心区域换热流体速度的不均匀性将减小。雷诺数和史蒂芬数对换热流体的相对速度分布有轻微影响,而更高的雷诺数可导致速度成比例地提高,史蒂芬数的增加可加快堆积床相变储热系统的储热过程。
New form of geodetic coordinate system taking two length quantity as coordinate parameters
Yimin SHI, Ziyang ZHU, Yeming FAN
《结构与土木工程前沿(英文)》 2009年 第3卷 第1期 页码 105-110 doi: 10.1007/s11709-009-0014-5
关键词: geodetic coordinate system meridian and parallel circle coordinate parameter the first fundamental form on the ellipsoidal surface latitudinal scale factor of length
Subcellular distribution and chemical form of Pb in hyperaccumulator
Yanqun ZU,Yuan LI,Huan MIN,Fangdong ZHAN,Li QIN,Jixiu WANG
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 250-258 doi: 10.1007/s11783-014-0643-3
关键词: Pb Arenaria orbiculata chemical forms subcellular distribution root exudates hydroponic culture
Generation of closed-form inverse kinematics for reconfigurable robots
ZHAO Jie, WANG Weizhong, GAO Yongsheng, CAI Hegao
《机械工程前沿(英文)》 2008年 第3卷 第1期 页码 91-96 doi: 10.1007/s11465-008-0013-6
关键词: different effectiveness generation reconfigurable algebraic
李昕,李冀
《中国工程科学》 2001年 第3卷 第9期 页码 81-85
文章试图应用现代管理的新理论,剖析知识经济时代企业的一种新形式--虚拟企业的产生和发展,指出其类型、特点及其优势,并对如何促进虚拟企业在我国的健康发展提出了见解。
Fabrication of form stable NaCl-Al2O3 composite for thermal energy storage by cold sintering process
Bilyaminu Suleiman, Qinghua Yu, Yulong Ding, Yongliang Li
《化学科学与工程前沿(英文)》 2019年 第13卷 第4期 页码 727-735 doi: 10.1007/s11705-019-1823-2
关键词: cold sintering process composite fabrication thermal energy storage phase change materials
Investigation of the structural form optimization methods of high-rise buildings
ZHANG Shihai, WANG Li, OU Jinping, WANG Guangyuan
《结构与土木工程前沿(英文)》 2007年 第1卷 第2期 页码 182-187 doi: 10.1007/s11709-007-0020-4
关键词: case-based reasoning computation KDD important development high-rise
Jiaxing GUO, Huan LIU, Yang JIANG, Dongquan HE, Qidong WANG, Fei MENG, Kebin HE
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 79-88 doi: 10.1007/s11783-013-0516-1
关键词: CO2 emission neighborhood type transportation household energy China
标题 作者 时间 类型 操作
Encapsulation of polyethylene glycol in cellulose-based porous capsules for latent heat storage and light-to-thermal
期刊论文
Beyond bag of latent topics: spatial pyramid matching for scene category recognition
Fu-xiang LU,Jun HUANG
期刊论文
Construction and humoral immune response of Epstein-Barr virus latent membrane protein 2 DNA vaccine
Jianqing PAN PhD, Qin ZHANG MD, Daowen WANG MD, PhD,
期刊论文
Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection
Yu Liao, Yufei Xiang, Zhiguang Zhou
期刊论文
Combination form analysis and experimental study of mechanical properties on steel sheet glass fiber
期刊论文
General closed-form inverse kinematics for arbitrary three-joint subproblems based on the product of
期刊论文
New form of geodetic coordinate system taking two length quantity as coordinate parameters
Yimin SHI, Ziyang ZHU, Yeming FAN
期刊论文
Subcellular distribution and chemical form of Pb in hyperaccumulator
Yanqun ZU,Yuan LI,Huan MIN,Fangdong ZHAN,Li QIN,Jixiu WANG
期刊论文
Generation of closed-form inverse kinematics for reconfigurable robots
ZHAO Jie, WANG Weizhong, GAO Yongsheng, CAI Hegao
期刊论文
Fabrication of form stable NaCl-Al2O3 composite for thermal energy storage by cold sintering process
Bilyaminu Suleiman, Qinghua Yu, Yulong Ding, Yongliang Li
期刊论文
Investigation of the structural form optimization methods of high-rise buildings
ZHANG Shihai, WANG Li, OU Jinping, WANG Guangyuan
期刊论文